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Article

Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.

Journal of molecular biology - 21 Mar 2008

Carafoli Federico, Saffell Jane L, Hohenester Erhard

Abstract excerpt

Activation of the fibroblast growth factor receptor (FGFR) by neural cell adhesion molecule (NCAM) is essential for NCAM-mediated neurite outgrowth. Previous peptide studies have identified two regions in the fibronectin type 3 (FN3)-like domains of NCAM as being important for these activities. Here we report the crystal structure of the NCAM FN3 domain tandem, which reveals an acutely bent domain arrangement....

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Share to Amino Acid Motifs
Share to Conserved Sequence
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibronectins

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Share to Protein Structure, Quaternary

Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

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Identifiers

PMID: 18261743
DOI: 10.1016/j.jmb.2008.01.030
PMCID: PMC2267215

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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