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Article

Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.

The Journal of biological chemistry - 15 Jul 2005

Day Bryan, To Catherine, Himanen Juha-Pekka, Smith Fiona M, Nikolov Dimitar B, Boyd Andrew W, Lackmann Martin

Abstract excerpt

Eph receptor tyrosine kinases (Ephs) function as molecular relays that interact with cell surface-bound ephrin ligands to direct the position of migrating cells. Structural studies revealed that, through two distinct contact surfaces on opposite sites of each protein, Eph and ephrin binding domai...

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Identifiers

PMID: 15901737
DOI: 10.1074/jbc.M504972200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15901737-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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