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Article

Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion.

The Journal of biological chemistry - 27 Apr 2007

Sjöstrand Dan, Carlsson Jonas, Paratcha Gustavo, Persson Bengt, Ibáñez Carlos F

Abstract excerpt

Most plasma membrane proteins are capable of sensing multiple cell-cell and cell-ligand interactions, but the extent to which this functional versatility is founded on their modular design is less clear. We have identified the third immunoglobulin domain of the Neural Cell Adhesion Molecule (NCAM) as the necessary and sufficient determinant for its interaction with Glial Cell Line-derived Neurotrophic Factor...

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Source

Identifiers

PMID: 17322291
DOI: 10.1074/jbc.M701588200

Genes

GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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