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Article

Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.

EMBO reports - 1 Mar 2008

Diop Soda Balla, Bertaux Karine, Vasanthi Dasari, Sarkeshik Ali, Goirand Benjamin, Aragnol Denise, Tolwinski Nicholas S, Cole Michael D, Pradel Jacques, Yates John R, Mishra Rakesh K, Graba Yacine, Saurin Andrew J

Abstract excerpt

Pontin (Pont) and Reptin (Rept) are paralogous ATPases that are evolutionarily conserved from yeast to human. They are recruited in multiprotein complexes that function in various aspects of DNA metabolism. They are essential for viability and have antagonistic roles in tissue growth, cell signalling and regulation of the tumour metastasis suppressor gene, KAI1, indicating that the balance of Pont and Rept...

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Identifiers

PMID: 18259215
DOI: 10.1038/embor.2008.8
PMCID: PMC2267392

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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