Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes.

Abstract excerpt

Intra-tumoral hypoxia (low oxygen [O(2)] level) is an independent indicator of unfavorable patient diagnosis, and increasing evidence demonstrates that hypoxia contributes to a more aggressive tumor phenotype. Adaptation to hypoxia is predominantly regulated by two structurally related hypoxia inducible factors, HIF-1alpha and HIF-2alpha, which activate the expression of genes involved in proliferation,...

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