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Article

Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2017

Wang Chuan, Nishijima Kazutoshi, Kitajima Shuji, Niimi Manabu, Yan Haizhao, Chen Yajie, Ning Bo, Matsuhisa Fumikazu, Liu Enqi, Zhang Jifeng, Chen Y Eugene, Fan Jianglin

Abstract excerpt

OBJECTIVE: Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis. APPROACH AND RESULTS: We generated transgenic (Tg) rabbits expressing the human EL...

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Identifiers

PMID: 28546217
DOI: 10.1161/ATVBAHA.117.309139
PMCID: PMC5513187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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