Article
Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.
The Journal of biological chemistry - 22 Oct 2004
Ishida Tatsuro, Choi Sungshin Y, Kundu Ramendra K, Spin Josh, Yamashita Tomoya, Hirata Ken-ichi, Kojima Yoko, Yokoyama Mitsuhiro, Cooper Allen D, Quertermous Thomas
Abstract excerpt
Endothelial lipase (EL) expression correlates inversely with circulating high density lipoprotein (HDL) cholesterol levels in genetic mouse models, and human genetic variation in this locus has been linked to differences in HDL cholesterol levels. These data suggest a role for EL in the development of atherosclerotic vascular disease. To investigate this possibility, LIPG-null alleles were bred onto the apoE...
Topics
- Alleles
- Animals
- Aorta
- Apolipoproteins E
- Arteriosclerosis
- Cell Adhesion
- Cholesterol, HDL
- Female
- Homozygote
- Immunohistochemistry
- Lipase
- Lipid Metabolism
- Lipids
- Lipoproteins