Article
Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish.
Matrix biology : journal of the International Society for Matrix Biology - 1 May 2022
Malbouyres Marilyne, Guiraud Alexandre, Lefrançois Christel, Salamito Mélanie, Nauroy Pauline, Bernard Laure, Sohm Frédéric, Allard Bruno, Ruggiero Florence
Abstract excerpt
The myotendinous junction (MTJ) is essential for the integrity of the musculoskeletal unit. Here, we show that gene ablation of the MTJ marker col22a1 in zebrafish results in MTJ dysfunction but with variable degrees of expression and distinct phenotypic classes. While most individuals reach adulthood with no overt muscle phenotype (class 1), a subset of the progeny displays severe movement impairment and die...
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