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The extracellular matrix: A dynamic niche in cancer progression

20 Feb 2012

Abstract excerpt

The local microenvironment, or niche, of a cancer cell plays important roles in cancer development. A major component of the niche is the extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical properties. Although tightly controlled during embryonic development and organ homeostasis, the ECM is commonly deregulated and becomes disorganized in...

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PMID: 22351925
DOI: 10.1083/jcb.201102147

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