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Article

Omics Overview of the SPARC Gene in Mesothelioma

11 Jul 2023

Abstract excerpt

The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. The SPARC gene is also involved in the epithelial-mesenchymal transition (EMT) process, which is a critical phenomenon leading to a more aggressive cancer cell phenotype. SPARC gene overexpression has shown to be associated with poor survival in the mesothelioma...

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PMID: 37509139
DOI: 10.3390/biom13071103

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