Article
Association of NAD(P)H:quinone oxidoreductase 1 polymorphism and Alzheimer's disease in Chinese.
Journal of molecular neuroscience : MN - 1 Mar 2008
Bian Jian-Tao, Zhao Hua-Lu, Zhang Zhen-Xin, Bi Xiu-Hua, Zhang Jun-Wu
Abstract excerpt
Several lines of evidence support a role of oxidative stress in the pathology of Alzheimer's disease (AD). NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. We examined association between the NQO1 C609T gene polymorphism and sporadic AD in a Chinese population comprising...
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