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Article

Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2018

Bi Rui, Zhang Wen, Zhang Deng-Feng, Xu Min, Fan Yu, Hu Qiu-Xiang, Jiang Hong-Yan, Tan Liwen, Li Tao, Fang Yiru, Zhang Chen, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia. Mitochondrial dysfunction has been widely reported in AD due to its important role in cellular metabolism and energy production. Complex IV (cytochrome c oxidase, COX) of mitochondrial electron transport chain, is particularly vulnerable in AD. Defects of COX in AD have been well documented, but there is little evidence to support the genetic...

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Identifiers

PMID: 30054583
DOI: 10.1038/s41386-018-0144-3
PMCID: PMC6135758

Genes

COX10
SURF1

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