Article
The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures.
The Journal of endocrinology - 1 Feb 2008
Young Julia M, Juengel Jennifer L, Dodds Kenneth G, Laird Mhairi, Dearden Peter K, McNeilly Alan S, McNatty Kenneth P, Wilson Theresa
Abstract excerpt
Bone morphogenetic proteins (BMPs) have been shown to influence the regulation of FSH synthesis and secretion at the level of the pituitary. Primary pituitary cells were harvested and cultured from Booroola ewes homozygous for a mutation in activin receptor-like kinase 6 (ALK6) also known as BMP receptor IB (BMPRIB), and from wild-type (WT) ewes to determine if the mutation caused alterations in FSH secretion in...
Topics
- Activins
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Protein 6
- Bone Morphogenetic Protein Receptors, Type I
- Bone Morphogenetic Proteins
- Cells, Cultured