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Article

The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.

The Journal of endocrinology - 1 Jun 2003

Fabre S, Pierre A, Pisselet C, Mulsant P, Lecerf F, Pohl J, Monget P, Monniaux D

Abstract excerpt

The hyperprolificacy phenotype of Booroola ewes is due to the presence of the FecB(B) allele at the FecB locus, recently identified as a single amino acid substitution (Q249R) in the bone morphogenetic protein (BMP) type-IB receptor (BMPR1B), and is associated with a more precocious differentiation of ovarian granulosa cells (GCs). To evaluate the consequences of the Booroola mutation on BMPR1B functions, the...

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Identifiers

PMID: 12773124
DOI: 10.1677/joe.0.1770435

Genes

BMPR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.PMID 12773124Read ↗

Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes.Semantic proximity Read ↗

Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6.Semantic proximity Read ↗

The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.Semantic proximity Read ↗

Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells.Semantic proximity Read ↗

Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation.Semantic proximity Read ↗

The Booroola (FecB) mutation is associated with smaller adrenal glands in young adult ewes.Semantic proximity Read ↗

Differential expression of BMP/SMAD signaling and ovarian-associated genes in the granulosa cells of FecB introgressed GMM sheep.Semantic proximity Read ↗

Mechanisms of action of the principal prolific genes and their application to sheep production.Semantic proximity Read ↗

Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep.Semantic proximity Read ↗

Ontogeny of ovarian follicle development in Booroola sheep fetuses that are homozygous carriers or non-carriers of the FecB gene.Semantic proximity Read ↗

Concentrations of progesterone, follistatin, and follicle-stimulating hormone in peripheral plasma across the estrous cycle and pregnancy in merino ewes that are homozygous or noncarriers of the Booroola gene.Semantic proximity Read ↗

Effects of the Booroola gene (FecB) on body weight, ovarian development and hormone concentrations during fetal life.Semantic proximity Read ↗

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