Article
The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.
The Journal of endocrinology - 1 Jun 2003
Fabre S, Pierre A, Pisselet C, Mulsant P, Lecerf F, Pohl J, Monget P, Monniaux D
Abstract excerpt
The hyperprolificacy phenotype of Booroola ewes is due to the presence of the FecB(B) allele at the FecB locus, recently identified as a single amino acid substitution (Q249R) in the bone morphogenetic protein (BMP) type-IB receptor (BMPR1B), and is associated with a more precocious differentiation of ovarian granulosa cells (GCs). To evaluate the consequences of the Booroola mutation on BMPR1B functions, the...
Topics
- Activins
- Analysis of Variance
- Animals
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Protein Receptors, Type I
- Bone Morphogenetic Proteins
- Cell Division
- Cell Line
- Cells, Cultured
- Female
- Genotype
- Granulosa Cells
- Growth Differentiation Factor 5