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Article

The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.

The Journal of endocrinology - 1 May 2001

Souza C J, MacDougall C, MacDougall C, Campbell B K, McNeilly A S, Baird D T

Abstract excerpt

Genetic variations in ovulation rate which occur in different breeds of sheep provide useful models to explore the mechanisms regulating the development of antral follicles. The Booroola gene, an autosomal mutation that affects ovulation rate, has been known for over two decades and despite intensive research it has not yet been identified. Using resources from human genome mapping and known data about gene...

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Identifiers

PMID: 11312159
DOI: 10.1677/joe.0.169r001

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.PMID 11312159Read ↗

Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells.Semantic proximity Read ↗

Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes.Semantic proximity Read ↗

The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.Semantic proximity Read ↗

The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q.Semantic proximity Read ↗

Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation.Semantic proximity Read ↗

Genetic mutations influencing ovulation rate in sheep.Semantic proximity Read ↗

Mechanisms of action of the principal prolific genes and their application to sheep production.Semantic proximity Read ↗

Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6.Semantic proximity Read ↗

Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep.Semantic proximity Read ↗

DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation.Semantic proximity Read ↗

Prolificacy genes in sheep: the French genetic programmes.Semantic proximity Read ↗

The Booroola (FecB) mutation is associated with smaller adrenal glands in young adult ewes.Semantic proximity Read ↗

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