Article
Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells.
Biology of reproduction - 1 Apr 2001
Wilson T, Wu X Y, Juengel J L, Ross I K, Lumsden J M, Lord E A, Dodds K G, Walling G A, McEwan J C, O'Connell A R, McNatty K P, Montgomery G W
Abstract excerpt
The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1.6 corpora lutea per cycle for each copy) and has been mapped to sheep chromosome 6q23-31, which is syntenic to human chromosome 4q21-25. Bone morphogenetic protein IB (BMP-IB) receptor (also known as ALK-6),...
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