Article
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study.
The Journal of clinical endocrinology and metabolism - 1 Apr 2008
Thamer Claus, Machann Jürgen, Stefan Norbert, Schäfer Silke A, Machicao Fausto, Staiger Harald, Laakso Markku, Böttcher Michael, Claussen Claus, Schick Fritz, Fritsche Andreas, Haring Hans-Ulrich
Abstract excerpt
CONTEXT: We recently demonstrated that single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-delta gene (PPARD), i.e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI). OBJECTIVE: The objective of the study was to determine whether the aforementioned PPARD SNPs...
Read the complete abstract on PubMed