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Article

The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Mar 2009

Silbernagel G, Stefan N, Hoffmann M M, Machicao-Arano F, Machann J, Schick F, Winkelmann B R, Boehm B O, Häring H U, Fritsche A, März W

Abstract excerpt

BACKGROUND: The L162V single nucleotide polymorphism in PPARA is suggested to play an important role in the pathogenesis of type 2 diabetes, obesity, and body fat composition. However, clinical evidence is controversial. OBJECTIVE: Our aim was to investigate the relationships of the L162V SNP with type 2 diabetes, pre-diabetes phenotypes, adiposity, and plasma lipid levels. In addition, we studied the...

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Source

Identifiers

PMID: 18726867
DOI: 10.1055/s-0028-1082069

Genes

PPARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition.PMID 18726867Read ↗

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A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPAR α) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitusSemantic proximity Read ↗

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The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome.Semantic proximity Read ↗

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population.Semantic proximity Read ↗

Association Between the PPARA L162V Polymorphism and Plasma Lipid LevelsSemantic proximity Read ↗

Screening of Peroxisome Proliferator-Activated Receptors (PPARs) α, γ and α Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-Ethnic Malaysian Population.Semantic proximity Read ↗

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Impact of the Pro12Ala Polymorphism of the PPAR‐Gamma 2 Gene on Metabolic and Clinical Characteristics in the Palestinian Type 2 Diabetic PatientsSemantic proximity Read ↗

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