Article
PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males.
BMC medical genetics - 16 Aug 2007
Uthurralt Julieta, Gordish-Dressman Heather, Bradbury Meg, Tesi-Rocha Carolina, Devaney Joseph, Harmon Brennan, Reeves Erica K, Brandoli Cinzia, Hansen Barbara C, Seip Richard L, Thompson Paul D, Price Thomas B, Angelopoulos Theodore J, Clarkson Priscilla M, Moyna Niall M, Pescatello Linda S, Visich Paul S, Zoeller Robert F, Gordon Paul M, Hoffman Eric P
Abstract excerpt
BACKGROUND: Of the five sub-phenotypes defining metabolic syndrome, all are known to have strong genetic components (typically 50-80% of population variation). Studies defining genetic predispositions have typically focused on older populations with metabolic syndrome and/or type 2 diabetes. We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better...
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