Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Moderate intergenerational and somatic instability of a 55-CTG repeat in transgenic mice.

Nature genetics - 1 Feb 1997

Gourdon G, Radvanyi F, Lia A S, Duros C, Blanche M, Abitbol M, Junien C, Hofmann-Radvanyi H

Abstract excerpt

Myotonic dystrophy (DM) is associated with the expansion of a (CTG)n trinucleotide repeat in the 3' untranslated region (UTR) of the DM protein kinase gene (DMPK). The (CTG)n repeat is polymorphic and varies in size between 5 and 37 repeats in unaffected individuals whereas in affected patients t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cosmids
Share to DNA, Complementary
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mosaicism

Share to Mutation

Share to Polymerase Chain Reaction

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 9020847
DOI: 10.1038/ng0297-190

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9020847-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Moderate intergenerational and somatic instability of a 55-CTG repeat in transgenic mice.PMID 9020847Read ↗

Hypermutable myotonic dystrophy CTG repeats in transgenic mice.Semantic proximity Read ↗

Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability.Semantic proximity Read ↗

CTG trinucleotide repeat "big jumps": large expansions, small mice.Semantic proximity Read ↗

Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities.Semantic proximity Read ↗

Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity.Semantic proximity Read ↗

Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.Semantic proximity Read ↗

The complex pathology of trinucleotide repeats.Semantic proximity Read ↗

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat.Semantic proximity Read ↗

Myotonic dystrophy: molecular windows on a complex etiology.Semantic proximity Read ↗

Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability.Semantic proximity Read ↗

Mouse tissue culture models of unstable triplet repeats: in vitro selection for larger alleles, mutational expansion bias and tissue specificity, but no association with cell division rates.Semantic proximity Read ↗

Individual-specific levels of CTG•CAG somatic instability are shared across multiple tissues in myotonic dystrophy type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.