Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

Nature genetics - 1 Feb 1997

Mangiarini L, Sathasivam K, Mahal A, Mott R, Seller M, Bates G P

Abstract excerpt

Six inherited neurodegenerative diseases are caused by a CAG/polyglutamine expansion, including spinal and bulbar muscular atrophy (SBMA), Huntington's disease (HD), spinocerebellar ataxia type 1 (SCA1), dentatorubral pallidoluysian atrophy (DRPLA) Machado-Joseph disease (MJD or SCA3) and SCA2. Normal and expanded HD allele sizes of 6-39 and 35-121 repeats have been reported, and the allele distributions for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Transgenic
Share to Mosaicism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Nerve Tissue Proteins

Share to Nuclear Proteins

Share to Polymerase Chain Reaction

Share to Reproducibility of Results

Source

Identifiers

PMID: 9020849
DOI: 10.1038/ng0297-197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.PMID 9020849Read ↗

Age‐dependent and tissue‐specific CAG repeat instability occurs in mouse knock‐in for a mutant Huntington's disease geneSemantic proximity Read ↗

Transgenic models of Huntington's disease.Semantic proximity Read ↗

Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions.Semantic proximity Read ↗

Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and LiverSemantic proximity Read ↗

Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?Semantic proximity Read ↗

Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.Semantic proximity Read ↗

Clinical aspects of CAG repeat diseases.Semantic proximity Read ↗

Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patientsSemantic proximity Read ↗

Huntington disease update: new insights into the role of repeat instability in disease pathogenesisSemantic proximity Read ↗

Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.Semantic proximity Read ↗

Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus.Semantic proximity Read ↗

Regional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.