Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

doi:10.1038/ng0297-197

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Article

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

Nature genetics - 1 Feb 1997

Mangiarini L, Sathasivam K, Mahal A, Mott R, Seller M, Bates G P

Abstract excerpt

Six inherited neurodegenerative diseases are caused by a CAG/polyglutamine expansion, including spinal and bulbar muscular atrophy (SBMA), Huntington's disease (HD), spinocerebellar ataxia type 1 (SCA1), dentatorubral pallidoluysian atrophy (DRPLA) Machado-Joseph disease (MJD or SCA3) and SCA2. N...

Topics

Animals
Female
Humans
Huntingtin Protein
Huntington Disease
Male
Mice
Mice, Transgenic
Mosaicism
Mutation
Nerve Tissue Proteins
Nuclear Proteins
Organ Specificity
Polymerase Chain Reaction
Reproducibility of Results
Transgenes
Trinucleotide Repeats

Source

Open in PubMed

Identifiers

PMID: 9020849
DOI: 10.1038/ng0297-197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9020849-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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