Article
A Likelihood-Based Approach for Missing Genotype Data.
Human heredity - 1 Jan 2010
D'Angelo Gina M, Kamboh M Ilyas, Feingold Eleanor
Abstract excerpt
Missing genotype data in a candidate gene association study can make it difficult to model the effects of multiple genetic variants simultaneously. In particular, when regression models are used to model phenotype as a function of SNP genotypes in several different genes, the most common approach is a complete case analysis, in which only individuals with no missing genotypes are included. But this can lead to...
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