Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy Response

5 Feb 2008

Abstract excerpt

Kruppel-like factor 6 (KLF6) is a tumor suppressor gene that is functionally inactivated in human cancer by loss of heterozygosity, somatic mutation, decreased expression, and increased alternative splicing into an oncogenic splice variant, KLF6-SV1. Here we show that increased expression of KLF6-SV1 is associated with decreased survival in patients with lung adenocarcinoma. In addition, KLF6-SV1 is a novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Kruppel-like factors research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18250346
DOI: 10.1158/0008-5472.can-07-2604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy ResponsePMID 18250346Read ↗

Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells.Semantic proximity Read ↗

KLF6-SV1 drives breast cancer metastasis and is associated with poor survival.Semantic proximity Read ↗

SMAD6 Contributes to Patient Survival in Non–Small Cell Lung Cancer and Its Knockdown Reestablishes TGF-β Homeostasis in Lung Cancer CellsSemantic proximity Read ↗

MiR-26a-5p Serves as an Oncogenic MicroRNA in Non-Small Cell Lung Cancer by Targeting FAF1Semantic proximity Read ↗

BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer.Semantic proximity Read ↗

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer☆Semantic proximity Read ↗

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.Semantic proximity Read ↗

KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis.Semantic proximity Read ↗

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of <i>KRAS</i>-mediated cell growthSemantic proximity Read ↗

WT1 enhances proliferation and impedes apoptosis in KRAS mutant NSCLC via targeting cMyc.Semantic proximity Read ↗

Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment.Semantic proximity Read ↗

Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.