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Article

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.

The Journal of clinical investigation - 1 Jul 2012

Sangodkar Jaya, Dhawan Neil S, Melville Heather, Singh Varan J, Yuan Eric, Rana Huma, Izadmehr Sudeh, Farrington Caroline, Mazhar Sahar, Katz Suzanna, Albano Tara, Arnovitz Pearlann, Okrent Rachel, Ohlmeyer Michael, Galsky Matthew, Burstein David, Zhang David, Politi Katerina, Difeo Analisa, Narla Goutham

Abstract excerpt

EGFR activation is both a key molecular driver of disease progression and the target of a broad class of molecular agents designed to treat advanced cancer. Nevertheless, resistance develops through several mechanisms, including activation of AKT signaling. Though much is known about the specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22653055
DOI: 10.1172/JCI62058
PMCID: PMC3386822

Genes

EGFR
FOXO1
KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22653055-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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