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Article

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of <i>KRAS</i>-mediated cell growth

17 Feb 2011

Abstract excerpt

SP/KLF (Specificity protein/Krüppel-like factor) transcription factors comprise an emerging group of proteins that may behave as tumour suppressors. Incidentally, many cancers that display alterations in certain KLF proteins are also associated with a high incidence of KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue) mutations. Therefore in the present paper we investigate whether SP/KLF proteins...

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PMID: 21171965
DOI: 10.1042/bj20100773

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