Article
Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells.
Cancer research - 1 Jun 2004
Ito Genshi, Uchiyama Mika, Kondo Masashi, Mori Shoichi, Usami Noriyasu, Maeda Osamu, Kawabe Tsutomu, Hasegawa Yoshinori, Shimokata Kaoru, Sekido Yoshitaka
Abstract excerpt
Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate tumor suppressor gene in prostate cancer and astrocytic glioma. Because KLF6 is located at chromosome 10p15, where non-small cell lung cancers (NSCLCs) also exhibit frequent allelic loss, we hypothesized that the inactivation of KLF6 is also involved in the development of NSCLC....
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