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Article

WT1 enhances proliferation and impedes apoptosis in KRAS mutant NSCLC via targeting cMyc.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015

Wu Chen, Wang Sihan, Xu Caihua, Tyler Andreas, Li Xingru, Andersson Charlotta, Oji Yusuke, Sugiyama Haruo, Chen Yijiang, Li Aihong

Abstract excerpt

BACKGROUND: A novel link between oncogenic KRAS signalling and WT1 was recently identified. We sought to investigate the role of WT1 and KRAS in proliferation and apoptosis. METHODS: KRAS mutations and WT1 (cMyc) expression were detected using Sanger sequencing and real-time PCR in 77 patients with non-small cell lung cancer (NSCLC). Overexpression and knockdown of WT1 were generated with plasmid and siRNA via...

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Source

Identifiers

PMID: 25613309
DOI: 10.1159/000369726

Genes

KRAS
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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