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Article

The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN- amplified neuroblastoma

31 May 2024

Abstract excerpt

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN -amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic...

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PMID: 38820154
DOI: 10.1126/sciadv.adm9449

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