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Article

Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor.

Journal of neuroscience research - 1 Oct 2008

Nieves-Cintrón Madeline, Caballero-Rivera Daniel, Silva Walter I, Navedo Manuel F, Lasalde-Dominicci José A

Abstract excerpt

The role of position L8', located in transmembrane domain 1 of the neuronal nicotinic alpha3 subunit, was characterized by using two-electrode voltage clamp in Xenopus oocytes. Four amino acids (Ala, Ser, Phe, and Tyr) were inserted at this conserved position, and the mutant subunit was coexpressed with either wild-type beta2 or beta4 subunits. These substitutions led to significant alterations in the...

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Identifiers

PMID: 18615639
DOI: 10.1002/jnr.21749
PMCID: PMC4586081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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