Article
Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease.
Transfusion - 1 May 2008
Afenyi-Annan Araba, Kail Melanie, Combs Martha R, Orringer Eugene P, Ashley-Koch Allison, Telen Marilyn J
Abstract excerpt
BACKGROUND: The Duffy glycoprotein (Fy) on red blood cells (RBCs) has been hypothesized to promote clearance of inflammatory cytokines, which may play a role in the pathogenesis of vasoocclusion in sickle cell disease (SCD). Persons with the African-type Fy(a-b-) phenotype--whose RBCs lack expression of Duffy--may less efficiently clear inflammatory cytokines. Therefore, the Duffy-negative genotype may be...
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