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Article

Duffy phenotype does not influence the clinical severity of sickle cell disease.

Clinical immunology (Orlando, Fla.) - 1 Sept 2000

Schnog J B, Keli S O, Pieters R A, Rojer R A, Duits A J

Abstract excerpt

The red blood cell Duffy antigen receptor for chemokines serves as a sink for the clearance of chemokines such as interleukin-8 (IL-8) from the circulation. We analyzed the impact of the Duffy phenotype on sickle cell disease (SCD) severity and serum IL-8 levels in 15 Duffy-positive and 36 Duffy-negative sickle cell patients. There was no difference in clinical severity between Duffy-positive and Duffy-negative...

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Source

Identifiers

PMID: 10964545
DOI: 10.1006/clim.2000.4884

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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