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Article

Blood clearance of the prion protein introduced by intravenous route in sheep is influenced by host genetic and physiopathologic factors.

Transfusion - 1 Apr 2008

Gayrard Véronique, Picard-Hagen Nicole, Viguié Catherine, Jeunesse Elisabeth, Tabouret Guillaume, Rezaei Human, Toutain Pierre-Louis

Abstract excerpt

BACKGROUND: The risk of transmissible spongiform encephalopathy (TSE) transmission by blood transfusion is dependent on the blood concentrations of the pathologic isoform of prion protein (PrPsc) but may also be influenced by blood concentrations of cellular PrP (PrPc). These concentrations are controlled by the blood clearance of PrP, which has never been evaluated. STUDY DESIGN AND METHODS: The blood (actually...

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Identifiers

PMID: 18248567
DOI: 10.1111/j.1537-2995.2007.01628.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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