Article
Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection.
PLoS pathogens - 1 Feb 2021
Salamat M Khalid F, Blanco A Richard Alejo, McCutcheon Sandra, Tan Kyle B C, Stewart Paula, Brown Helen, Smith Allister, de Wolf Christopher, Groschup Martin H, Becher Dietmar, Andréoletti Olivier, Turner Marc, Manson Jean C, Houston E Fiona
Abstract excerpt
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from zoonotic transmission of bovine spongiform encephalopathy (BSE). Documented cases of vCJD transmission by blood transfusion necessitate on-going risk reduction measures to protect blood supplies, such as leucodepletion (removal of white blood cells, WBCs). This study set out to determine the risks of prion transmission by transfusion...
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