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Article

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997

Bossers A, Belt PBGM, Raymond G J, Caughey B, de Vries R, Smits M A

Abstract excerpt

Prion diseases are natural transmissible neurodegenerative disorders in humans and animals. They are characterized by the accumulation of a protease-resistant scrapie-associated prion protein (PrPSc) of the host-encoded cellular prion protein (PrPC) mainly in the central nervous system. Polymorphisms in the PrP gene are linked to differences in susceptibility for prion diseases. The mechanisms underlying these...

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Identifiers

PMID: 9144167
DOI: 10.1073/pnas.94.10.4931
PMCID: PMC24608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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