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Article

Sindbis virus nsP1 functions in negative-strand RNA synthesis.

Journal of virology - 1 Feb 1991

Wang Y F, Sawicki S G, Sawicki D L

Abstract excerpt

A mutation at nucleotide 1101 of Sindbis virus ts11 nsP1 caused temperature-sensitive negative-strand synthesis and suppressed the 24R phenotype, which is caused by a mutation in nsP4. Nonstructural proteins synthesized and accumulated by ts11 at 40 degrees C did not cause the reactivation of negative-strand synthesis upon return to 30 degrees C and did not prevent the formation of new replication complexes at 30...

Topics

Animals
Capsid
Cell Line
Kinetics
Mutation
Phenotype
RNA, Viral
Sindbis Virus
Suppression, Genetic
Temperature
Templates, Genetic
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Core Proteins

Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1824787
DOI: 10.1128/JVI.65.2.985-988.1991
PMCID: PMC239844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1824787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Sindbis virus nsP1 functions in negative-strand RNA synthesis.PMID 1824787Read ↗

Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4.Semantic proximity Read ↗

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Role for Conserved Residues of Sindbis Virus Nonstructural Protein 2 Methyltransferase-Like Domain in Regulation of Minus-Strand Synthesis and Development of Cytopathic InfectionSemantic proximity Read ↗

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