Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alphavirus minus-strand RNA synthesis: identification of a role for Arg183 of the nsP4 polymerase.

Journal of virology - 1 Sept 2002

Fata Cori L, Sawicki Stanley G, Sawicki Dorothea L

Abstract excerpt

A partially conserved region spanning amino acids 142 to 191 of the Sindbis virus (SIN) nsP4 core polymerase is implicated in host restriction, elongation, and promoter recognition. We extended the analysis of this region by substituting Ser, Ala, or Lys for a highly conserved Arg183 residue immediately preceding its absolutely conserved Ser184-Ala-Val-Pro-Ser188 sequence. In chicken cells, the nsP4 Arg183...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aedes
Share to Arginine
Share to Chick Embryo

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Gene Expression Regulation, Viral

Share to Sindbis Virus

Share to Viral Nonstructural Proteins

Share to Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 12163582
DOI: 10.1128/jvi.76.17.8632-8640.2002
PMCID: PMC136981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alphavirus minus-strand RNA synthesis: identification of a role for Arg183 of the nsP4 polymerase.PMID 12163582Read ↗

Modification of Asn374 of nsP1 Suppresses a Sindbis Virus nsP4 Minus-Strand Polymerase MutantSemantic proximity Read ↗

Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4.Semantic proximity Read ↗

Suppressor mutations that allow sindbis virus RNA polymerase to function with nonaromatic amino acids at the N-terminus: evidence for interaction between nsP1 and nsP4 in minus-strand RNA synthesis.Semantic proximity Read ↗

Regulation of alphavirus 26S mRNA transcription by replicase component nsP2.Semantic proximity Read ↗

Requirement for an aromatic amino acid or histidine at the N terminus of Sindbis virus RNA polymerase.Semantic proximity Read ↗

Changes of the secondary structure of the 5' end of the Sindbis virus genome inhibit virus growth in mosquito cells and lead to accumulation of adaptive mutations.Semantic proximity Read ↗

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Semantic proximity Read ↗

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.Semantic proximity Read ↗

An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.Semantic proximity Read ↗

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.Semantic proximity Read ↗

Sindbis virus nsP1 functions in negative-strand RNA synthesis.Semantic proximity Read ↗

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.