Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4.

doi:10.1016/0042-6822(90)90052-s

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Article

Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4.

Virology - 1 Jan 1990

Sawicki D, Barkhimer D B, Sawicki S G, Rice C M, Schlesinger S

Abstract excerpt

Minus strand RNA synthesis by the positive strand alphaviruses, Sindbis and Semliki Forest viruses, normally occurs early in infection, is coupled to synthesis of viral nonstructural proteins and to formation of viral replication complexes, and terminates and does not occur late in infection. Pre...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Cells, Cultured
Cloning, Molecular
Molecular Sequence Data
Mutation
Plasmids
RNA, Viral
Sindbis Virus
Temperature
Viral Core Proteins
Viral Nonstructural Proteins
Virus Replication

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