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Article

Functional role of conserved transmembrane segment 1 residues in human sodium-dependent vitamin C transporters.

Biochemistry - 4 Mar 2008

Varma Saaket, Campbell Christine E, Kuo Shiu-Ming

Abstract excerpt

Sodium-dependent vitamin C transporters, SVCT1 and SVCT2, are the only two known proteins for the uptake of ascorbate, the active form of vitamin C. Little structural information is available for SVCTs, although a transport activity increase from pH 5.5 to 7.5 suggests a functional role of one or more conserved histidines (p K a approximately 6.5). Confocal fluorescence microscopy and uptake kinetic analyses were...

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PMID: 18247577
DOI: 10.1021/bi701666q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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