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Article

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.

The Journal of clinical investigation - 1 Apr 2010

Corpe Christopher P, Tu Hongbin, Eck Peter, Wang Jin, Faulhaber-Walter Robert, Schnermann Jurgen, Margolis Sam, Padayatty Sebastian, Sun He, Wang Yaohui, Nussbaum Robert L, Espey Michael Graham, Levine Mark

Abstract excerpt

Levels of the necessary nutrient vitamin C (ascorbate) are tightly regulated by intestinal absorption, tissue accumulation, and renal reabsorption and excretion. Ascorbate levels are controlled in part by regulation of transport through at least 2 sodium-dependent transporters: Slc23a1 and Slc23a2 (also known as Svct1 and Svct2, respectively). Previous work indicates that Slc23a2 is essential for viability in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20200446
DOI: 10.1172/JCI39191
PMCID: PMC2847422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.PMID 20200446Read ↗

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