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Article

N-Glycosylation is required for Na+-dependent vitamin C transporter functionality.

Biochemical and biophysical research communications - 12 Sept 2008

Subramanian Veedamali S, Marchant Jonathan S, Reidling Jack C, Said Hamid M

Abstract excerpt

The human sodium-dependent vitamin C transporters (hSVCT1 and hSVCT2) mediate cellular uptake of ascorbic acid. Both these transporters contain potential sites for N-glycosylation in their extracellular domains (Asn-138, Asn-144 [hSVCT1]; Asn-188, Asn-196 [hSVCT2]), however the role of N-glycosylation in transporter function is unexplored. On the basis of the result that tunicamycin decreased (14)C-ascorbic acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18619416
DOI: 10.1016/j.bbrc.2008.06.120
PMCID: PMC2528843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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