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Article

Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function.

Biochimica et biophysica acta - 1 Jun 2011

Pajor Ana M, Sun Nina N, Joshi Aditya D, Randolph Kathleen M

Abstract excerpt

Citric acid cycle intermediates, including succinate and citrate, are absorbed across the apical membrane by the NaDC1 Na+/dicarboxylate cotransporter located in the kidney and small intestine. The secondary structure model of NaDC1 contains 11 transmembrane helices (TM). TM7 was shown previously to contain determinants of citrate affinity, and Arg-349 at the extracellular end of the helix is required for...

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Identifiers

PMID: 21073858
DOI: 10.1016/j.bbamem.2010.11.007
PMCID: PMC3046213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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