Article
Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2008
Le-Niculescu H, McFarland M J, Ogden C A, Balaraman Y, Patel S, Tan J, Rodd Z A, Paulus M, Geyer M A, Edenberg H J, Glatt S J, Faraone S V, Nurnberger J I, Kuczenski R, Tsuang M T, Niculescu A B
Abstract excerpt
We had previously identified the clock gene D-box binding protein (Dbp) as a potential candidate gene for bipolar disorder and for alcoholism, using a Convergent Functional Genomics (CFG) approach. Here we report that mice with a homozygous deletion of DBP have lower locomotor activity, blunted responses to stimulants, and gain less weight over time. In response to a chronic stress paradigm, these mice exhibit a...
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