Article
A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.
Neuropharmacology - 1 Jun 2011
Saba Laura M, Bennett Beth, Hoffman Paula L, Barcomb Kelsey, Ishii Takao, Kechris Katerina, Tabakoff Boris
Abstract excerpt
Genetic influences on the predisposition to complex behavioral or physiological traits can reflect genetic polymorphisms that lead to altered gene product function, and/or variations in gene expression levels. We have explored quantitative variations in an animal's alcohol consumption, using a genetical genomic/phenomic approach. In our studies, gene expression is correlated with amount of alcohol consumed, and...
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