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Article

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2018

Ferguson Laura B, Ozburn Angela R, Ponomarev Igor, Metten Pamela, Reilly Matthew, Crabbe John C, Harris R Adron, Mayfield R Dayne

Abstract excerpt

Transcriptome-based drug discovery has identified new treatments for some complex diseases, but has not been applied to alcohol use disorder (AUD) or other psychiatric diseases, where there is a critical need for improved pharmacotherapies. High Drinking in the Dark (HDID-1) mice are a genetic model of AUD risk that have been selectively bred (from the HS/Npt line) to achieve intoxicating blood alcohol levels...

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Identifiers

PMID: 29251283
DOI: 10.1038/npp.2017.301
PMCID: PMC5916369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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