Article
Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2011
Rodríguez-Carballo Edgardo, Ulsamer Arnau, Susperregui Antonio R G, Manzanares-Céspedes Cristina, Sánchez-García Eva, Bartrons Ramon, Rosa José Luis, Ventura Francesc
Abstract excerpt
Osteoblast differentiation depends on the coordinated network of evolutionary conserved transcription factors during bone formation and homeostasis. Evidence indicates that bone morphogenetic protein (BMP) and Wnt proteins regulate several steps of skeletal development. Here, we provide a molecular description of the cooperative effects of BMP and Wnt canonical pathway on the expression of the early osteogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.