Article
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.
Nature reviews. Microbiology - 1 Mar 2008
Cowen Leah E
Abstract excerpt
The emergence of drug resistance in pathogenic microorganisms provides an excellent example of microbial evolution that has had profound consequences for human health. The widespread use of antimicrobial agents in medicine and agriculture exerts strong selection for the evolution of drug resistance. Selection acts on the phenotypic consequences of resistance mutations, which are influenced by the genetic...
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