Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

Abstract excerpt

The survival of all organisms depends critically upon interactions with the environment, mediated largely through the action of small molecules.Small molecules can provide the nutrients to support life (195), mediate communication between organisms (25,76, 238), or exert toxicity that threatens viability (86, 183).The discovery of small molecules with exquisite potency and selective toxicity to microbes...

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