Article
Incapacitating the evolutionary capacitor: Hsp90 modulation of disease.
Current opinion in genetics & development - 1 Jun 2008
Yeyati Patricia L, van Heyningen Veronica
Abstract excerpt
The nature-nurture argument surrounding the mechanisms of disease causation cannot be resolved, as the roles of genes and environment are inextricably entwined. Environmental fluctuation is clearly a major modifier of phenotype, as well as a promoter of evolutionary change. Both types of variability can be mediated by the stress response pathway, with the Hsp90 chaperone family as key components. Hsp90 has been...
Topics
- Animals
- Disease
- Evolution, Molecular
- Gene Dosage
- Gene Expression Regulation, Developmental
- HSP90 Heat-Shock Proteins
- Humans
- Inheritance Patterns
- Models, Biological
- Phenotype
- Plants