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Article

Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.

American journal of hypertension - 1 Mar 2008

Vimaleswaran Karani S, Franks Paul W, Barroso Inês, Brage Soren, Ekelund Ulf, Wareham Nicholas J, Loos Ruth J F

Abstract excerpt

BACKGROUND: The endothelial nitric-oxide synthase (NOS3) gene encodes the enzyme (eNOS) that synthesizes the molecule nitric oxide, which facilitates endothelium-dependent vasodilation in response to physical activity. Thus, energy expenditure may modify the association between the genetic variation at NOS3 and blood pressure. METHODS: To test this hypothesis, we genotyped 11 NOS3 polymorphisms, capturing all...

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Source

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Identifiers

PMID: 18246059
DOI: 10.1038/ajh.2007.69
PMCID: PMC2714087

Genes

NOS3
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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