Article
Deep-targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity-dependent associations with post-exercise hypotension.
Physiological reports - 1 Nov 2017
Pescatello Linda S, Schifano Elizabeth D, Ash Garrett I, Panza Gregory A, Corso Lauren M L, Chen Ming-Hui, Deshpande Ved, Zaleski Amanda, Cilhoroz Burak, Farinatti Paulo, Taylor Beth A, O'Neill Rachel J, Thompson Paul D
Abstract excerpt
In previous studies, we found an endothelial nitric oxide synthase gene (NOS3) variant rs2070744 associated with the ambulatory blood pressure (BP) response following bouts of moderate and vigorous intensity acute exercise, termed post-exercise hypotension (PEH). In a validation cohort, we sequenced NOS3 exons for associations with PEH Obese (30.9 ± 3.6 kg.m-2) African American (n = 14) [AF] and Caucasian (n = 9)...
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